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KMID : 0882420120830040520
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Korean Journal of Medicine
2012 Volume.83 No. 4 p.520 ~ p.524
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Everolimus-Induced Interstitial Pneumonitis in a Patient with Metastatic Renal Cell Carcinoma: a Case Report
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Lee So-ra
Kim Young-Min
Jung Ji-Yun
Kim Hyung-Joon
Kim Do-Hyung
Park Keon-Woo
Lee Soon-Il
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Abstract
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Everolimus, an inhibitor of the mammalian target of rapamycin, is an active agent against metastatic renal cell carcinoma. Treatment with everolimus prolongs progression-free survival in patients with clear cell-type renal cell carcinoma that has progressed on vascular endothelial growth factor receptor tyrosine kinase inhibitors, such as sunitinib and/or sorafenib. Everolimus-induced interstitial pneumonitis is not rare and is sometimes fatal. Due to the potential for pulmonary toxicity due to everolimus, it is recommended that pulmonary complications be periodically evaluated. We report a case of everolimus-associated interstitial pneumonitis in a patient with metastatic renal cell carcinoma.
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KEYWORD
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Clear cell metastatic renal cell carcinoma, Everolimus, Interstitial pneumonitis
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